Genetic Oxidative Testing


Free radicals are everywhere and are capable of damaging your cells and genetic material. The body generates free radicals primarily by turning your food into energy. Other free radicals are in the food you eat and the air you breathe. Free radicals come in many sizes and chemical combinations and can damage the instruction codes in DNA. Among many other ramifications they can contribute to the possibility of bad cholesterol molecules getting trapped in an artery wall. Depending upon your symptoms we might test you and come up with a plan to minimize their imapact on your body.

Below is a more detailed explanation of what we know and look for when doing Genetic Oxidative Testing.

Single Nucleotide Polymorphism (SNP)

Oxidative Stress

The genes listed below (SOD1, SOD2, SOD3, GPX1) provide the code for making enzymes that are part of the body’'s natural defense against free radicals found in cells. When someone has an excess in free radicals (oxidative stress), this can be damaging to cells, and can add to health issues. These defensive enzymes support health by inactivating free radicals in a two-set process, explained below.

The Superoxide dismutases (SOD1, SOD2, SOD3) perform the first step.

Catalase (CAT) and glutathione peroxidase (GPX1) perform the second step. People with a hereditary variation in these genes may have reduced ability to defend against inactive free radicals. 

SOD1: Hereditary variations in this gene can affect the ability to remove free radicals from cells. This may increase risk for oxidative stress, especially when other changes to the oxidative stress pathway are present.

SOD2: Found in the mitochondria, hereditary variations in the gene can alter the movement and ability of the enzyme to enter the mitochondria. This can alter activity of the enzyme.

SOD3: This enzyme binds endothelial walls to protect against free radicals. Hereditary variations in the gene can impair its ability to bind to the walls.

GPX1: Found in the mitochondria, hereditary variations in this gene can reduce the activity of the enzyme.

CAT: Hereditary variations in this gene can reduce the activity of the enzyme. *

We welcome all of your questions.  Once we have discovered how your body has been responding to free radicals, we can create a therapy plan personalized to your individual needs.


• Information supplied by NeuroScience, our primary lab testing resource -